Gerresheimer AG has developed tamper evident prefilled syringes, combining ease of use and precise dosing in one package.
The Gx TELC system comprises an integrated adapter and a closure produced using two-component technology to achieve a moulded hard-soft combination.
First, a Covestro copolycarbonate is injected into the mould to produce the adapter, which is followed by the injection of the thermoplastic elastomer to mould the soft component - the cap. The TPE is bonded to the thermoplastic by means of melt adhesion, forming a firm adhesive layer, according to Martin Doebler, medical technology specialist at Covestro.
The combination of closure and adapter in a single component simplifies the manufacturing process and makes the product cost-efficient.
The new product is also claimed to be easy to use, with the operator only having to mount one connected part on the syringes.
Turning the cap to open the syringes releases tabs that spread and prevent the cap from closing again.
This tamper-evident feature means that the syringe cannot be opened and closed without detection.
Gerresheimer is displaying the Gx TELC integrated syringes during its debut exhibition at the Pharmapack 2019 trade show in Paris, 6-7 Feb.
The Dusseldorf medical specialist has used Covestro's Apec 1745 polycarbonate as the material for the syringe adaptor, according to a Covestro release 31 Jan.
The transparent high-temperature polycarbonate has high heat resistance and can be sterilised using conventional methods such as gamma rays or ethylene oxide.
The excellent dimensional stability and dimensional accuracy at high temperatures of the material mean that the entire component will not warp after hot steam sterilisation at 143 °C, according to Covestro.
The market for prefilled syringes is currently experiencing strong growth – for example, in systems for the treatment of chronic diseases such as rheumatism. The ease of use of these products is key to ensuring that patients are administered the intended dose of the active substance.